Misoprostol Dosage: What You Need to Know

If you’ve been prescribed misoprostol, the biggest question is usually “how much should I take?” The answer depends on why you’re using it. Misoprostol works in different ways – it can trigger uterine contractions, protect the stomach lining, or help ripen the cervix. Below you’ll find the most common dosing schedules, why they differ, and the safety pointers you shouldn’t ignore.

Common Uses and Typical Doses

Medical abortion (up to 10 weeks): Most doctors give 800 µg (four 200 µg tablets) taken vaginally, buccally, or sublingually every 3 hours. You’ll usually take the first dose at the clinic, then repeat the dose at home. Some providers split the total into 400 µg doses taken 12 hours apart – the key is to follow the exact schedule they wrote for you.

Labor induction (after 37 weeks): The usual plan starts with 25 µg (one 200 µg tablet split into eight pieces) taken orally or vaginally every 2 hours. The dose may be increased to 50 µg if contractions are weak. The goal is to start labor gently, so doctors watch the timing closely.

Cervical ripening before a surgical abortion or procedure: A typical regimen is 400 µg taken vaginally 24 hours before the procedure. Some clinicians use 200 µg doses at 12‑hour intervals instead. The route (vaginal vs. buccal) can affect how quickly the cervix softens.

Prevention of stomach ulcers (especially when taking NSAIDs): The standard dose is 200 µg taken orally four times a day with food. It’s a low dose compared to the obstetric uses, and you’ll stay on it as long as you need NSAID protection.

Other off‑label uses: For conditions like postpartum hemorrhage, doctors may give 600‑800 µg intramuscularly as a single shot. This is a one‑time dose and should only be administered by a trained professional.

Safety Tips and When to Call a Doctor

Never guess a dose – always use the exact tablet split or a pill cutter. If you miss a dose, take it as soon as you remember unless it’s within an hour of the next scheduled dose – then skip the missed one and continue as planned.

Watch for common side effects: cramping, diarrhea, nausea, or mild fever. These usually go away within a day or two. If you get strong, constant pain, heavy bleeding (soaking more than two pads per hour), or a fever over 38 °C, call your provider immediately.

Pregnant women using misoprostol for anything other than a prescribed medical abortion should not self‑medicate. The drug can cause serious complications if taken at the wrong stage of pregnancy.

Store the tablets in a cool, dry place. They lose potency if they get too hot or humid, so keep them away from the bathroom cabinet.

Finally, keep a list of any other meds you’re taking – especially other prostaglandins, blood thinners, or NSAIDs – and share it with your doctor. Interactions can change how misoprostol works and may increase side‑effects.

Bottom line: misoprostol dosing isn’t one‑size‑fits‑all. Follow the schedule your clinician gave you, split tablets carefully, and know the warning signs that need urgent care. With the right approach, you’ll get the benefit you need while keeping risks low.