Prednisolone Side Effects – Quick Guide

If you’ve been prescribed prednisolone, you’re probably wondering what it might do to your body. It’s a powerful steroid that can calm inflammation fast, but it also brings a handful of side effects. Below we break down the most frequent issues, why they happen, and simple steps to keep them in check.

Common Side Effects You’ll Notice

Most people feel at least a few of these after starting prednisolone:

• Increased appetite and weight gain – steroids tell your brain you’re hungry, so meals can seem more appealing.
• Mood swings or anxiety – the drug can affect hormone balance, leading to irritability or nervousness.
• Sleep trouble – many users report difficulty falling asleep or staying asleep.
• Upset stomach – nausea, indigestion, or a feeling of “butterflies” are common, especially on an empty stomach.
• Blood sugar rise – if you have diabetes, prednisolone may push glucose levels higher, so keep a close eye on your meter.

These side effects usually show up early and often ease off as your body adjusts or the dose drops.

When to Call Your Doctor

Some reactions need medical attention right away. If you notice any of these, pick up the phone:

• Severe stomach pain or vomiting blood – could mean an ulcer forming.
• Sudden swelling in your face, legs, or abdomen – fluid retention can become serious.
• High fever, chills, or persistent cough – steroids lower immunity, making infections harder to fight.
• Vision changes or severe headaches – rare but possible signs of increased eye pressure.
• Persistent mood changes, depression, or thoughts of self‑harm – mental health shifts can be intense with steroids.

If any of these pop up, don’t wait. A quick chat with your doctor can prevent bigger problems.

To keep side effects low, take prednisolone exactly as prescribed. Never skip doses or stop abruptly; tapering helps your body readjust. Pair the medication with a balanced diet rich in calcium and vitamin D – steroids can thin bones over time. A short walk after meals often eases stomach upset and lifts mood.

Remember, prednisolone works best when you’re aware of how it feels and what to watch for. By staying informed and communicating openly with your healthcare team, you’ll get the anti‑inflammatory benefits while keeping unwanted side effects in check.