Alesse vs Other Pills: Compare Birth Control Options

When you're choosing a birth control pill, Alesse, a combination oral contraceptive containing levonorgestrel and ethinyl estradiol. Also known as a low-dose hormonal pill, it's one of the most commonly prescribed options for women seeking reliable cycle control and acne management. But is it the right fit for you? Many women switch between pills like Yaz, Loestrin, Ortho Tri-Cyclen, and Microgynon, looking for fewer side effects, better mood stability, or lower cost. Alesse isn't the strongest or the weakest—it’s the middle ground. That’s why it’s a go-to for people who want balance, not extremes.

What sets Alesse apart from other pills? Its hormone levels are on the lower end: 150 mcg of levonorgestrel and 20 mcg of ethinyl estradiol. Compare that to Yaz, which has drospirenone (a different type of progestin), or Loestrin 24, which has a shorter placebo week. Alesse’s formula is older but proven. Studies show it’s just as effective as newer pills at preventing pregnancy, but some users report less bloating and fewer mood swings than with pills containing drospirenone. If you’ve had bad reactions to pills with spironolactone-like progestins, Alesse might be easier on your system. But if you’re dealing with severe acne or PMS, pills like Yaz or Beyaz might offer extra benefits.

Cost matters too. Alesse is often cheaper than brand-name alternatives because it’s been around for decades and has multiple generic versions. You’ll find it priced similarly to Loestrin 20 or Tri-Sprintec. Insurance usually covers it, but even without insurance, you can find it for under $20 a month at many pharmacies. That’s a big deal if you’re comparing it to newer pills that cost $50 or more. And unlike some pills that require you to take them at the exact same time every day, Alesse gives you a little more wiggle room—though consistency still boosts effectiveness.

Side effects? Most women tolerate Alesse well. The usual suspects—nausea, breast tenderness, spotting—are mild and fade after a few months. But if you’re prone to migraines with aura, have a history of blood clots, or are over 35 and smoke, Alesse isn’t safe for you. That’s true for all combination pills. The key isn’t just which pill you pick—it’s whether your health history matches the risks. Always talk to your doctor about your full medical picture before starting any hormonal birth control.

Below, you’ll find real comparisons between Alesse and other popular pills. We’ve pulled from detailed guides on how each one affects your body, what users report, and how they stack up in cost, convenience, and comfort. No fluff. Just what you need to decide if Alesse is still your best option—or if another pill might work better for your life.